Hydrochloric Acid → HCID 70364106, compound

HRID 1651463Notes

Reaction equation

HRID 1651463 reaction equation
[C:1]([C:5]1[S:9][C@@H:8]([C:10]([OH:12])=[O:11])[N:7]([C:13](=[O:35])[C@H:14]([CH2:30][CH2:31][CH2:32][CH2:33][NH2:34])[NH:15][C@H:16]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].O.[ClH:37]>O1CCCC1>[ClH:37].[C:1]([C:5]1[S:9][C@@H:8]([C:10]([OH:12])=[O:11])[N:7]([C:13](=[O:35])[C@H:14]([CH2:30][CH2:31][CH2:32][CH2:33][NH2:34])[NH:15][C@H:16]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 14032384HCID 14032384, compound

Product 1

HCID 70364106HCID 70364106, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 5-t-butyl-3-[N2 -(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-lysyl]-2,3-dihydro-1,3,4-thiadiazole-2-(S)-carboxylic acid (0.97 g, prepared using the appropriate starting material by the process of Example 4) in tetrahydrofuran (20 ml) and water (20 ml) was treated with 1N hydrochloric acid (3.8 ml). The solvents were evaporated and the residue was taken up in a mixture of dichloromethane and toluene. The solvents were removed by evaporation to give the title product (0.9 g) as a white

Workup

  1. customThe solvents were evaporated
  2. additionthe residue was taken up in a mixture of dichloromethane and toluene
  3. customThe solvents were removed by evaporation

Sources & evidence

ORD record
ord-28bb87a4f232483596d211d7bfef4f33
Source dataset
uspto-grants-1990_05
Patent number
US04927822

Reaction notes

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