Hydrochloric Acid → HCID 14071503, compound

HRID 1651856Notes

Reaction equation

HRID 1651856 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[C:5]([NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)(=[O:7])[CH3:6].[Cl-].[Al+3].[Cl-].[Cl-].Cl>C(Cl)CCl>[CH3:2][C:1]([C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[CH2:17][CH:9]([NH:8][C:5](=[O:7])[CH3:6])[CH2:10]2)=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 12452137N-(2,3-Dihydro-1H-inden-2-yl)acetamide

Product 1

HCID 14071503HCID 14071503, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

24.4 g (0.31 mol) of acetyl chloride, followed by 35.5 g (0.20 mol) of 2-acetamido-indane are added, with stirring, to a suspension of 68 g (0.51 mol) of anhydrous aluminium chloride in 350 ml of ethylene chloride. In the course of this the reaction temperature rises to approx. 50° C. Stirring is continued for a further 3 hours, the product is decomposed by means of ice and concentrated hydrochloric acid, and the organic phase is separated off and evaporated.

Workup

  1. additionare added
  2. customrises to approx. 50° C
  3. customthe organic phase is separated off
  4. customevaporated

Sources & evidence

ORD record
ord-83c797ee24ad4f89afdc032b3324c133
Source dataset
uspto-grants-1990_05
Patent number
US04929754

Reaction notes

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