Hydrochloric Acid → 146422-39-1

HRID 1653720Notes

Reaction equation

HRID 1653720 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[ClH:11]>CO.O=[Pt]=O>[ClH:11].[NH2:1][C:2]1[CH:3]([C:4]([OH:6])=[O:5])[CH2:7][CH2:8][CH2:9][N:10]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 729302-Aminonicotinic acid

Product 1

HCID 70342450146422-39-1Yield 103.5%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

2-Aminonicotinic acid (0.912 g, 6.6 mmol) was dissolved in 90% methanol (137 ml) and conc. HCl (3.5 ml, 40 mmol) was added. The solution was hydrogenated over PtO2 (200 mg) in a Parr shaker apparatus at room temperature and 29 psig for 2 hours. Filtration and evaporation gave 1.22 g (100%) oily product identified by ir 3300-2500, 1724 cm-1.

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-8f8ee3086af5403cb541c9e84ed1ae4f
Source dataset
uspto-grants-1995_04
Patent number
US05403845

Reaction notes

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