Hydrochloric Acid → HCID 70342222, compound

HRID 1653723Notes

Reaction equation

HRID 1653723 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([OH:10])=[O:9])[N:3]=1.[ClH:11]>CO.O=[Pt]=O>[ClH:11].[NH2:1][C:2]1[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([OH:10])=[O:9])[N:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 3516526-Aminopyridine-2-carboxylic acid

Product 1

HCID 70342222HCID 70342222, compoundYield 80.3%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

2-Aminopyridine-6-carboxylic acid (Farinaco. Ed. Sci. 1959, 14, 594; 2.01 g, 14.5 mmol) was dissolved in 90% methanol (200 ml) and conc. HCl (7.2 ml, 87.4 mmol) was added. The solution was hydrogenated over PtO2 (340 mg) in a Parr shaker apparatus at room temperature and 29 psig for 2 hours. Filtration and evaporation gave 2.08 g (80%) crude white crystals identified as the product by 300 MHz nmr and ir 1724 cm-1.

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-8a47683716814850b11379c01c30608a
Source dataset
uspto-grants-1995_04
Patent number
US05403845

Reaction notes

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