反应详情

Palladium (II) acetate (0.15 g, 0.67 mmol) was added to a stirred solution of isobutyl 5-ethenyl-2-hydroxybenzoate (6.6 g, 30 mmol) and 4-iodo-N-2-pyridinylbenzenesulfonamide (10.8 g, 30 mmol) in dimethylacetamide (40 ml) and tributylamine (10 ml, 42 mmol) at 95° C. After 100 min. the solution was filtered and evaporated at 50°-60° C. (bath temp.) until solid material appeared. The mixture was diluted with isopropanol (0.5 l) and chilled in a freezer. The product was filtered off to yield 7.1g (52%).

1. filtrationAfter 100 min. the solution was filtered
2. customevaporated at 50°-60° C. (bath temp.) until solid material
3. additionThe mixture was diluted with isopropanol (0.5 l)
4. temperaturechilled in a freezer
5. filtrationThe product was filtered off
6. customto yield 7.1g (52%)