Bis(3-aminopropyl)amine → HCID 178420360, compound

HRID 1654994Notes

Reaction equation

HRID 1654994 reaction equation
[CH2:1]([CH2:4][NH:5][CH2:6][CH2:7][CH2:8][NH2:9])[CH2:2][NH2:3].[CH:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1)=O.[NH:18]1[CH:22]=[C:21]([CH:23]=O)[N:20]=[CH:19]1>C(O)C>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:10][NH:3][CH2:2][CH2:1][CH2:4][NH:5][CH2:6][CH2:7][CH2:8][NH:9][CH2:23][C:21]1[N:20]=[CH:19][NH:18][CH:22]=1

Participants

5

Reactant 3

HCID 5942Bis(3-aminopropyl)amineHCID 142732-PyridinecarboxaldehydeHCID 764281H-Imidazole-4-carbaldehyde

Product 1

HCID 178420360HCID 178420360, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was synthesized as described in Example 4 by using 3,3'-diaminodipropylamine (4) (0.655 g, 0.005 mol) in dry ethanol and the two aldehydes pyridine-2-carboxaldehyde (2) (0.535 g, 0.005 mol) and imidazole-4-carboxaldehyde (34) (0.48 g, 0.005 mol) in that order. After catalytic hydrogenation and purification by silica gel column chromatography, the pure free base (36) was obtained (0.79 g). The product was transformed into the hydrochloride salt as described in Ex: 4

Workup

  1. customThis compound was synthesized
  2. customAfter catalytic hydrogenation and purification by silica gel column chromatography

Sources & evidence

ORD record
ord-22b9b818463f48f8b8e4a4ba8a00676f
Source dataset
uspto-grants-1995_04
Patent number
US05410052

Reaction notes

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