Hydracrylonitrile → 2-Cyanoethyl 3-oxobutanoate

HRID 1655304Notes

Reaction equation

HRID 1655304 reaction equation
[OH:1][CH2:2][CH2:3][C:4]#[N:5].[CH3:6][C:7]1[O:13]C(C)(C)O[C:9](=[O:10])[CH:8]=1>C(N(CC)CC)C>[C:9]([O:1][CH2:2][CH2:3][C:4]#[N:5])(=[O:10])[CH2:8][C:7]([CH3:6])=[O:13]

Participants

4

Reactant 2

HCID 8011HydracrylonitrileHCID 793682,2,6-Trimethyl-4H-1,3-dioxin-4-one

Product 1

HCID 123604062-Cyanoethyl 3-oxobutanoate

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A mixture of 16.33 g (0.23 mole) of 3-hydroxy-propionitrile and 28.4 g (0.20 mole) of 2,2,6-trimethyl-1,3-dioxen-4-one in the presence of 0.1 ml of triethylamine is heated to 90°-100° C. for 4 hrs 30 mins.

Workup

  1. temperatureis heated to 90°-100° C. for 4 hrs 30 mins

Sources & evidence

ORD record
ord-f867b4015bbf4bb48277a737c0a9cdd3
Source dataset
uspto-grants-1993_10
Patent number
US05250543

Reaction notes

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