反应详情

A mixture of 0.95 g of 2-chloro-4-(3,5-difluorophenoxy)phenol, 0.54 g of p-chlorobenzyl alcohol, 1.01 g of triphenylphosphine, 0.65 g of diethylazadicarboxylate and 90 ml of tetrahydrofuran was stirred at room temperature. After 48 hours, the reaction mixture was concentrated, and 50 ml of diethyl ether was added thereto. The precipitate were removed by filtration, and the filtrate was concentrated. The residue was subjected to silica gel chromatography to give 0.87 g of 4-chloro-1-[2-chloro-4-(3,5-difluorophenoxy)phenoxy]methylbenzene. Yield, 62%. m.p.: 95.3° C.

1. concentrationthe reaction mixture was concentrated
2. addition50 ml of diethyl ether was added
3. customThe precipitate were removed by filtration
4. concentrationthe filtrate was concentrated