反应详情

The mesogenic group (R)-4'-(1-ethoxycarbonyl-1-ethoxy)-phenyl-4-[4-(9-decenyloxy)-phenyl]-benzoate 1 was synthesized as follows. 4'-(9-decenyloxy)biphenyl-4 carboxylic acid 1 was prepared by reacting hydroxybiphenyl carboxylic acid methyl ester with 10-bromo-1-decene in DMF containing NaH followed by hydrolysis. Compound 2 was synthesized by coupling of ethyl-(S)-2 hydroxypropionate with p-(benzyloxy)phenol. Hydrogenolysis of 2 by Palladium on activated charcoal led to the formation of the phenol derivative 3. The final product 1 was obtained by reaction of the acid chloride of 1 with 3 in the presence of pyridine.

1. customThe mesogenic group (R)-4'-(1-ethoxycarbonyl-1-ethoxy)-phenyl-4-[4-(9-decenyloxy)-phenyl]-benzoate 1 was synthesized
2. custom4'-(9-decenyloxy)biphenyl-4 carboxylic acid 1 was prepared
3. customfollowed by hydrolysis