Trifluoroacetic acid → HCID 68138499, compound

HRID 1657563Notes

Reaction equation

HRID 1657563 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([C:16]2(O)[CH2:21][CH2:20][C:19](=[O:22])[CH2:18][CH2:17]2)[CH:10]=1.C(=O)(O)[O-].[Na+]>>[F:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([C:16]2[CH2:21][CH2:20][C:19](=[O:22])[CH2:18][CH:17]=2)[CH:10]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 65917941HCID 65917941, compound

Product 1

HCID 68138499HCID 68138499, compound

Procedure

To 25 ml. of well stirred trifluoroacetic acid, 5.35 g. of 4-(p-fluoro-o-tolyl)-4-hydroxycyclohexanone (obtained as in Example 47) is added. After about 10 minutes, the mixture is poured into an excess of aqueous sodium bicarbonate solution and the material that precipitates is extracted with ether. The extract is washed with aqueous sodium bicarbonate solution, water and brine and then evaporated to dryness to give 4(p-fluoro-o-tolyl)-3-cyclohexen-1-one.

Workup

  1. customthe material that precipitates
  2. extractionis extracted with ether
  3. washThe extract is washed with aqueous sodium bicarbonate solution, water and brine
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-020e5ef3c77148ed922c06c09e20a50e
Source dataset
uspto-grants-1976_06
Patent number
US03960961

Reaction notes

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