4-Piperidineethanol → HCID 54509260, compound

HRID 1657600Notes

Reaction equation

[CH:1]([O:4][C:5]1[CH:18]=[CH:17][C:16]2[S:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[S:19]([CH3:22])(=[O:21])=[O:20])[N:8]([CH2:23][CH2:24][CH2:25]Cl)[C:7]=2[CH:6]=1)([CH3:3])[CH3:2].[OH:27][CH2:28][CH2:29][CH:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1.C(=O)(O)[O-].[Na+]>CN(C)C=O>[CH:1]([O:4][C:5]1[CH:18]=[CH:17][C:16]2[S:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[S:19]([CH3:22])(=[O:21])=[O:20])[N:8]([CH2:23][CH2:24][CH2:25][N:33]3[CH2:34][CH2:35][CH:30]([CH2:29][CH2:28][OH:27])[CH2:31][CH2:32]3)[C:7]=2[CH:6]=1)([CH3:3])[CH3:2]

Participants

Conditions

Temperature: 150 °C

Procedure

A mixture of 2-isopropoxy-6-methylsulphonyl-10-(3-chloropropyl)phenothiazine (20 g.), 4-hydroxyethylpiperidine (6.4 g.) and sodium bicarbonate (16.5 g.) in dimethylformamide (170 cc.) is heated at 150°C. for 7 hours 30 minutes with stirring. The reaction mixture is then treated under the conditions mentioned in Example 1. 2-Isopropoxy-6-methylsulphonyl-10-[3-(4-hydroxyethylpiperidino)propyl]phenothiazine (9.0 g.), melting at about 50°C., is thus obtained.

Workup

additionThe reaction mixture is then treated under the conditions

Sources & evidence

ORD record: ord-d50849881ca64b6facb50aa99b77d854
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03961055

Reaction notes

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