Benzyl Bromide → HCID 13397856, compound

HRID 1658529Notes

Reaction equation

HRID 1658529 reaction equation
C(N(CC)CC)C.[CH3:8][C:9]1[CH:14]=[C:13]([CH3:15])[N:12]=[C:11]2[S:16][NH:17][C:18](=[O:19])[C:10]=12.[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CC(C)=O>[CH2:20]([N:17]1[C:18](=[O:19])[C:10]2[C:11](=[N:12][C:13]([CH3:15])=[CH:14][C:9]=2[CH3:8])[S:16]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 8471TriethylamineHCID 173760Isothiazolo(5,4-b)pyridin-3(2H)-one, 4,6-dimethyl-

Product 1

HCID 13397856HCID 13397856, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

Triethylamine (approximately 3 ml) is added to a slurry of 5.0 g of 4,6-dimethylisothiazolo-(5,4-b)-pyridin-3(2H)-one in 120 ml reagent grade acetone until the mixture becomes homogeneous. A solution of 4.0 g (0.024 m) of benzyl bromide in 20 ml acetone is then added. The reaction mixture is stirred for 3 days at room temperature and is then stripped to dryness. The residue is washed once with deionized water, then with 95% 2B ethanol, then ether and dried to give the product.

Workup

  1. washThe residue is washed once with deionized water
  2. dry with materialwith 95% 2B ethanol, then ether and dried
  3. customto give the product

Sources & evidence

ORD record
ord-bd9889eed4f0420ba8ab015478bf896e
Source dataset
uspto-grants-1976_06
Patent number
US03965107

Reaction notes

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