1-Chloropropane → HCID 21525506, compound

HRID 1658791Notes

Reaction equation

HRID 1658791 reaction equation
[Br:1][C:2]1[C:28]([Br:29])=[CH:27][C:5]2[N:6]([C:19](=[O:26])[CH2:20][N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[C:7]3[N:18]=[CH:17][CH:16]=[CH:15][C:8]=3[C:9]3[N:10]([C:11](=[O:14])[NH:12][N:13]=3)[C:4]=2[CH:3]=1.[H-].[Na+].[CH2:32](Cl)[CH2:33][CH3:34]>CN(C)C=O.C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[C:28]([Br:29])=[CH:27][C:5]2[N:6]([C:19](=[O:26])[CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25])[C:7]3[N:18]=[CH:17][CH:16]=[CH:15][C:8]=3[C:9]3[N:10]([C:11](=[O:14])[N:12]([CH2:32][CH2:33][CH3:34])[N:13]=3)[C:4]=2[CH:3]=1

Participants

6

Reactant 3

HCID 108991-ChloropropaneHCID 24758Sodium hydrideHCID 21525532HCID 21525532, compound

Product 1

HCID 21525506HCID 21525506, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 7237O-XyleneSolvent

Procedure

In the manner given in Example 25, to 6,7-dibromo -9-[(diethylamino)acetyl]-3H-pyrido[3,2-c]-s-triazolo-[4,3-a][1,5]benzodiazepin-3-one in dimethylformamide is added a solution of sodium hydride in mineral oil. The mixture is allowed to react at about 95° C. for 40 minutes and after cooling propyl chloride in xylene is added. The mixture is kept at 95°-100° C. for a period of 22 hours, evaporated and worked up as in exanmple 25 to give 6,7-dibromo-2,9-dihydro-2-propyl-9-[(diethylamino)acetyl]-3H-pyrido[3,2-c]-s-triazolo[4,3-a][1,5]-benzodiazepin-3-one.

Workup

  1. customto react at about 95° C. for 40 minutes
  2. additionis added
  3. customevaporated

Sources & evidence

ORD record
ord-ca90081f5f6c4c38b186d7f3f951dea9
Source dataset
uspto-grants-1976_06
Patent number
US03966736

Reaction notes

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