Dimethylformamide → HCID 21955784, compound

HRID 1658797Notes

Reaction equation

HRID 1658797 reaction equation
C([C:3]1[C:29]([CH2:30][CH3:31])=[CH:28][C:6]2N(C(=O)CN3CCCC3)C3N=CC=CC=3C3N(C(=O)NN=3)[C:5]=2[CH:4]=1)C.[H-].[Na+].[N:34]1(CCCCl)CCCC1.C[N:44](C)[CH:45]=[O:46]>C1(C)C(C)=CC=CC=1>[N:34]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:28][C:29]=2[CH:30]=[CH:31][C:45](=[O:46])[N:44]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 113210281-(3-Chloropropyl)-pyrrolidineHCID 21525569HCID 21525569, compound

Product 1

HCID 21955784HCID 21955784, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In the manner given in Example 25, to 6,7-diethyl-2,9-dihydro-9-(pyrrolidinoacetyl)-3H-pyrido[3,2-c]-s-triazolo[4,3-a][1,5]benzodiazepin-3-one in dimethylformamide is added a solution of sodium hydride in mineral oil. The mixture is allowed to react at about 95° C. for 40 minutes and after cooling (3-pyrrolidinopropyl)chloride in xylene is added. The mixture is kept at 95°-100° C. for a period of 22 hours, evaporated and worked up as in example 25 to give 6,7-diethyl-2,9-dihydro-2-(3-pyrrolidinopropyl)-9-(pyrrolidinoacetyl)-3H-pyrido[3,2-c]-s-triazolo[4,3-a]]1,5]benzodiazepin-3-one.

Workup

  1. customto react at about 95° C. for 40 minutes
  2. additionis added
  3. customevaporated

Sources & evidence

ORD record
ord-b8652dde62e34c598a3a50db0b5c4664
Source dataset
uspto-grants-1976_06
Patent number
US03966736

Reaction notes

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