Isopropanol → HCID 70533607, compound

HRID 1659955Notes

Reaction equation

HRID 1659955 reaction equation
[C:1]1([C:7]2[N:16]=[C:15](Cl)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][C@H:28]([CH3:30])[NH:27][CH2:26][C@@H:25]1[CH3:31].C(O)(C)C>Cl>[C:1]1([C:7]2[N:16]=[C:15]([N:27]3[CH2:26][C@H:25]([CH3:31])[N:24]([C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][N:18]=4)[CH2:29][C@@H:28]3[CH3:30])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 809774-Chloro-2-phenylquinazolineHCID 70531620HCID 70531620, compound

Product 1

HCID 70533607HCID 70533607, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture containing 8.4 g (0.03 mole) of 2-phenyl-4-chloroquinazoline, 6.3 g (0.0335 mole) of 1-(2-pyridyl)-cis-2,5-dimethylpiperazine and 200 ml of isopropanol was refluxed for 6 hrs. The resulting reaction mixture was filtered after cooling to room temperature. A crystalline solid was obtained. The crude product was dissolved in 3N hydrochloric acid and extracted with ether. The aqueous acidic solution was adjusted to pH=7.5 and filtered. Yield of crystalline solid was 4.3 g, m.p. 68°-70° C.

Workup

  1. temperaturewas refluxed for 6 hrs
  2. customThe resulting reaction mixture
  3. filtrationwas filtered
  4. customA crystalline solid was obtained
  5. extractionextracted with ether
  6. filtrationfiltered

Sources & evidence

ORD record
ord-830f16c12ea14b588d840aca2f67d7ce
Source dataset
uspto-grants-1981_12
Patent number
US04306065

Reaction notes

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