Isopropanol → HCID 25056266, compound

HRID 1660767Notes

Reaction equation

HRID 1660767 reaction equation
[NH2:1][C@H:2]([CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=1[F:28])[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][C:8](=[O:12])[C@H:7]1[CH2:13][O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:5].[C:29]([OH:38])(=[O:37])[C@@H:30]([C@H:32]([C:34]([OH:36])=[O:35])[OH:33])[OH:31].CC(O)C>CC(C)=O.C(O)C.O>[C:34]([CH:32]([CH:30]([C:29]([OH:38])=[O:37])[OH:31])[OH:33])([OH:36])=[O:35].[NH2:1][C@H:2]([CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=1[F:28])[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][C:8](=[O:12])[C@H:7]1[CH2:13][O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:5]

Participants

6

Reactant 3

HCID 3776IsopropanolHCID 444305L-Tartaric acidHCID 25022354Evogliptin

Product 1

HCID 25056266HCID 25056266, compoundYield 101.9%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 19096565Water ethanolSolvent

Procedure

55 mg of the compound obtained in Example 11 was dissolved in 0.56 mL of acetone to which a solution of 26 mg of L-tartaric acid in 0.35 mL of ethanol/water (9/1(v/v)) was then slowly added, followed by stirring for 30 min. 0.56 mL of 2-propanol was added thereto, followed by stirring for 10 min and filtration to afford 77 mg of the title compound as a solid.

Workup

  1. additionwas then slowly added
  2. stirringby stirring for 10 min
  3. filtrationfiltration

Sources & evidence

ORD record
ord-4a7e0fe50e384fd4a0b6b750e59b48db
Source dataset
uspto-grants-2011_10
Patent number
US08030315B2

Reaction notes

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