反应详情

温度

40 °C

A mixture of (2-chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid ethyl ester (0.325 g, 1.03 mmol), 0.5 N aqueous solution of LiOH (2 mL), and THF (2 mL) is stirred for 1 h at 40° C. The reaction mixture is allowed to cool to rt and then acidified by addition of 0.5 N HCl aqueous solution. The resulting precipitate is collected by vacuum filtration to provide the title compound as a white solid: ES-MS: 288.0 [M+H]+; single peak at tR=3.00 min (System 1).

1. temperatureto cool to rt
2. filtrationThe resulting precipitate is collected by vacuum filtration