2-Aminothiazole → HCID 178508067, compound

HRID 1662901Notes

Reaction equation

HRID 1662901 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[N:7]([O-])=O.[Na+].Cl.[NH2:12][C:13]1[N:17]2[CH2:18][CH2:19][CH2:20][N:16]2[C:15](=[O:21])[CH:14]=1.C([O-])(=O)C.[Na+]>Cl.O.C(O)C>[NH2:12][C:13]1[N:17]2[CH2:18][CH2:19][CH2:20][N:16]2[C:15](=[O:21])[C:14]=1/[N:7]=[N:1]/[C:2]1[S:3][CH:4]=[CH:5][N:6]=1

Participants

8

Reactant 4

HCID 21552-AminothiazoleHCID 517045Sodium AcetateHCID 23668193Sodium NitriteHCID 674357713-Amino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one--hydrogen chloride (1/1)

Product 1

HCID 178508067HCID 178508067, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

0.57 g of 2-aminothiazole is solubilized in 3 ml of 6N hydrochloric acid. The medium is cooled to zero degrees, and then a solution of 0.39 g of sodium nitrite in 3 ml of water is added over 3 minutes. The medium is then kept stirring for 10 minutes between 0 and 5° C. A mixture of 1 g of 3-amino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one hydrochloride, 5 ml of ethanol, 5 ml of water and 1.7 g of sodium acetate is added to the reaction medium.

Workup

  1. temperatureThe medium is cooled to zero degrees
  2. additionis added to the reaction medium

Sources & evidence

ORD record
ord-4a8c1dd8d6ce45bb9065e332ff929e23
Source dataset
uspto-grants-2011_10
Patent number
US08034124B2

Reaction notes

Loading…