N-Hydroxyphthalimide → O-[(3,5-Dimethyl-1,2-oxazol-4-yl)methyl]hydroxylamine--hydrogen chloride (1/1)

HRID 1663118Notes

Reaction equation

[OH:1][N:2]1C(=O)C2=CC=CC=C2C1=O.[Cl:13][CH2:14][C:15]1[C:16]([CH3:21])=[N:17][O:18][C:19]=1[CH3:20]>>[ClH:13].[CH3:21][C:16]1[C:15]([CH2:14][O:1][NH2:2])=[C:19]([CH3:20])[O:18][N:17]=1

Participants

Reactant 2

HCID 10665N-Hydroxyphthalimide

HCID 88246Isoxazole, 4-(chloromethyl)-3,5-dimethyl-

Product 1

HCID 19974948O-[(3,5-Dimethyl-1,2-oxazol-4-yl)methyl]hydroxylamine--hydrogen chloride (1/1)

Procedure

Prepared by a similar procedure as described for preparation 13. Starting materials: N-hydroxyphthalimide and 4-(chloromethyl)-3,5-dimethylisoxazole (Aldrich). 13C-NMR (DMSO-d6) δ 169.7, 159.6, 108.2, 64.4, 10.8, 9.5.

Workup

customPrepared by a similar procedure
customas described for preparation 13

Sources & evidence

ORD record: ord-ea2af63e688d4c47bac688bbdd909134
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08034811B2

Reaction notes

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