Lithium Carbonate → HCID 86625161, compound

HRID 1663394Notes

Reaction equation

HRID 1663394 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([OH:11])[C:9]=1[OH:10])[CH:5]=[O:6].C(=O)([O-])[O-].[Li+].[Li+].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH2:23]Cl>[I-].C([N+](CCCC)(CCCC)CCCC)CCC.CN(C=O)C.C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([OH:11])[C:9]=1[O:10][CH2:23][C:22]1[CH:25]=[CH:26][CH:27]=[C:20]([O:19][CH3:18])[CH:21]=1)[CH:5]=[O:6]

Participants

7

Reactant 3

HCID 11125Lithium CarbonateHCID 699943-Methoxybenzyl chlorideHCID 854055-Bromo-3,4-dihydroxybenzaldehyde

Product 1

HCID 86625161HCID 86625161, compound

Reagents, catalysts & solvents 3

HCID 67553Tetrabutylammonium IodideCatalystHCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 3-bromo-4,5-dihydroxy-benzaldehyde (1 g), lithium carbonate (314 mg), 3-methoxybenzyl chloride (742 μl) and a catalytic amount of tetrabutylammonium iodide in DMF (5 ml) was stirred at 60° C. for 17 h. The mixture was diluted with ethyl acetate and washed with water. The organic layer was dried (MgSO4), filtered and concentrated in vacuo.

Workup

  1. washwashed with water
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6c2e2a4cff604669adff8b56816eea98
Source dataset
uspto-grants-2011_10
Patent number
US08034945B2

Reaction notes

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