Hydrochloric Acid → Neotame

Temperature

68.5 °C

2,4,6-Trineopentyl-1,3,5-trioxane (3.3 g, about 10.7 mmol) was dissolved in toluene (3 mL) and 0.5 mL of 20% aqueous hydrochloric acid was added. The mixture was refluxed under nitrogen atmosphere for 1 hour (68-69° C.). The NMR analysis showed the only signals corresponding to 3,3-dimethylbutyraldehyde and benzene. The mixture was neutralized with sodium bicarbonate to pH=7 and the organic layer was transferred to the stirred suspension of aspartame (9.4 g, 31.9 mmol) and Pd/C (0.4 g) in methanol (150 mL) under nitrogen. Nitrogen was removed by hydrogen and the reaction mixture was vigorously stirred for 14 hours under light hydrogen pressure (<1 psi). Then, the mixture was filtered through Celite. The Celite layer was washed with methanol (25 mL) and evaporated under vacuum to half (about 80-90 mL), filtered and water (about 100 mL) was added to the residue. The mixture was gently evaporated under vacuum to remove methanol (without heating to keep low temperature of about 0-5° C.), and then kept at room temperature for 24 hours. The precipitate was filtered off, washed with water (30 mL) and dried under vacuum for 14 hours to give neotame (6.88 g, 57%).

1. customNitrogen was removed by hydrogen
2. filtrationThen, the mixture was filtered through Celite
3. washThe Celite layer was washed with methanol (25 mL)
4. customevaporated under vacuum to half (about 80-90 mL)
5. filtrationfiltered
6. additionwater (about 100 mL) was added to the residue
7. customThe mixture was gently evaporated under vacuum
8. customto remove methanol (without heating to keep low temperature of about 0-5° C.)
9. waitkept at room temperature for 24 hours
10. filtrationThe precipitate was filtered off
11. washwashed with water (30 mL)
12. customdried under vacuum for 14 hours

ORD record

ord-470de45b471b424695e9a8aecdd06f93

Source dataset

uspto-grants-2011_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08034969B2