Potassium Carbonate → 6-(3-aminophenoxy)-N-methylimidazo[1,2-b]pyridazine-2-carboxamide

HRID 1663753Notes

Reaction equation

HRID 1663753 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([NH:13][CH3:14])=[O:12])[N:10]=2)[N:7]=1.C(=O)([O-])[O-].[K+].[K+].[NH2:21][C:22]1[CH:23]=[C:24]([OH:28])[CH:25]=[CH:26][CH:27]=1>CN(C)C=O>[NH2:21][C:22]1[CH:23]=[C:24]([CH:25]=[CH:26][CH:27]=1)[O:28][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([NH:13][CH3:14])=[O:12])[N:10]=2)[N:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 115683-AminophenolHCID 574410266-iodo-N-methylimidazo[1,2-b]pyridazine-2-carboxamide

Product 1

HCID 575055106-(3-aminophenoxy)-N-methylimidazo[1,2-b]pyridazine-2-carboxamideYield 36%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 6-iodo-N-methylimidazo[1,2-b]pyridazine-2-carboxamide (0.30 g, 0.99 mmol), N,N-dimethylformamide (3.0 mL), potassium carbonate (275 mg, 1.99 mmol) and 3-aminophenol (163 mg, 1.49 mmol) as starting materials and in the same manner as in Example 91, the title compound (0.10 g, 36%) was obtained as a dark brown powder.

Sources & evidence

ORD record
ord-03f40eef1d464a1ebf4d6d462effc2c5
Source dataset
uspto-grants-2011_10
Patent number
US08034812B2

Reaction notes

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