Triethylamine → HCID 57505562, compound

HRID 1663826Notes

Reaction equation

HRID 1663826 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[F:24])[O:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([NH:15][C:16]([CH:18]3[CH2:20][CH2:19]3)=[O:17])[N:14]=2)[N:11]=1.[C:25]([N:32]1C=CN=C1)(N1C=CN=C1)=[O:26].Cl.N[O:39][CH2:40][CH:41]([CH3:43])[CH3:42].C(N(CC)CC)C>CN(C)C=O>[F:24][C:23]1[CH:22]=[CH:21][C:4]([O:5][C:6]2[CH:7]=[CH:8][C:9]3[N:10]([CH:12]=[C:13]([NH:15][C:16]([CH:18]4[CH2:20][CH2:19]4)=[O:17])[N:14]=3)[N:11]=2)=[CH:3][C:2]=1[NH:1][C:25]([NH:32][O:39][CH2:40][CH:41]([CH3:43])[CH3:42])=[O:26]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 12696238O-(2-Methylpropyl)hydroxylamine--hydrogen chloride (1/1)HCID 57505446N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Product 1

HCID 57505562HCID 57505562, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (200 mg, 0.611 mmol), 1,1′-carbonyldiimidazole (297 mg, 1.833 mmol), 1-(aminooxy)-2-methylpropane hydrochloride (230 mg, 1.833 mmol), triethylamine (0.25 mL, 1.833 mmol) and N,N-dimethylformamide (6.0 mL), and by a reaction in the same manner as in Example 200, the title compound (170 mg, 63%) was obtained as colorless crystals.

Workup

  1. customby a reaction in the same manner as in Example 200

Sources & evidence

ORD record
ord-e371ea5d81494c3ba77354be483923df
Source dataset
uspto-grants-2011_10
Patent number
US08034812B2

Reaction notes

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