反应详情

LiOH.H2O (25 mg, 0.58 mmol) was added to a solution of N-biphenyl-4-yl-N-methyl-malonamic acid ethyl ester (116 mg, 0.39 mmol) in a mixture of Methanol (0.6 mL), THF (1.5 mL) and H2O (0.4 mL). The resulting mixture was stirred at ambient temperature for 2 hrs. The reaction mixture was concentrated to get a residue. The residue was diluted with water, acidified with conc. HCl. The precipitate was collected and dried to afford 100 mg (95.24%) of N-biphenyl-4-yl-N-methyl-malonamic acid

1. concentrationThe reaction mixture was concentrated
2. customto get a residue
3. customThe precipitate was collected
4. customdried