反应详情

To a solution of 2-butoxy-8-methoxyadenine (5 g, 14.2 mmol) in dimethylformamide (50 ml) were added 1,3-dibromobutane (7.2 ml) and potassium carbonate (9.2 g), and the mixture was stirred at room temperature for 1.5 hour. Water (200 ml) and ethyl acetate (75 ml) were added thereto, and the mixture was extracted, and further extracted with ethyl acetate (75 ml) twice. The organic layers were combined, dried over magnesium sulfate, filtered, and the solvent was distilled off under reduced pressure. To the residue was added diethyl ether (25 ml), and the precipitated crystals were collected by filtration, washed with ether (5 ml), and dried to give the subtitle compound (3.6 g) as a white solid. Yield: 71%

1. extractionthe mixture was extracted
2. extractionfurther extracted with ethyl acetate (75 ml) twice
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. distillationthe solvent was distilled off under reduced pressure
6. additionTo the residue was added diethyl ether (25 ml)
7. filtrationthe precipitated crystals were collected by filtration
8. washwashed with ether (5 ml)
9. customdried