反应详情

Z-(L)Glu(OtBu)—OH (5 g), HOBT hydrate (2.5 g) and EDCI hydrochloride (3.1 g) were dissolved in DCM/THF (1/1, 42 ml). After 15 min stirring, 1-ethoxycarbonylpiperazine (2.6 g) was added and the stirring continued overnight at RT. 150 ml of EA and 60 ml of a NaHCO3 solution were added to the mixture and the phases were separated. The org. phase was washed with 60 ml of a 1M NaHSO4 solution and 60 ml of a NaCl solution, dried (Na2SO4) and evaporated off. After HV drying, 7 g of the desired compound were obtained.

1. customthe stirring continued overnight
2. customat RT
3. customthe phases were separated
4. washphase was washed with 60 ml of a 1M NaHSO4 solution and 60 ml of a NaCl solution
5. dry with materialdried (Na2SO4)
6. customevaporated off
7. customAfter HV drying