HRID1666773

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID311

Citric acid

C6H8O7

HCID1030

1,2-Propylene glycol

C3H8O2

HCID21618

(1,3-Dioxolan-4-yl)methanol

C4H8O3

2 次

结构：CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F

HCID39212

未命名化合物

结构：CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1

HCID114811

Florfenicol

C12H14Cl2FNO4S

PRODUCTS

生成物

结构：CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F

HCID86602307

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

溶剂HCID31374

Dimethylacetamide

C4H9NO

PROCEDURE

实验过程

The NMP or dimethylacetamide, citric acid, propylene glycol, and approximately 90% of the PEG 300 or glycerol formal required for each formulation were charged to the compounding vessel and mixed well. The florfenicol and flunixin meglumine were added with mixing until all solids were dissolved. The volume was adjusted with the remaining PEG 300 or glycerol formal.

WORKUP

后处理

additionwere charged to the compounding vessel
additionmixed well
additionwith mixing until all solids
dissolutionwere dissolved

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f33629d272154f038dc051a2ce161aaf
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08044102B2
来源说明: uspto-grants-2011_10

反应 SMILES

C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(O)C(O)C.C1OCOC1CO.[CH3:26][S:27]([C:30]1[CH:31]=[CH:32][C:33]([C@@H:36]([OH:46])[C@H:37]([NH:40][C:41]([CH:43]([Cl:45])[Cl:44])=[O:42])[CH2:38][F:39])=[CH:34][CH:35]=1)(=[O:29])=[O:28].[CH3:47][C:48]1[C:53]([NH:54][C:55]2[N:60]=[CH:59][CH:58]=[CH:57][C:56]=2[C:61]([OH:63])=[O:62])=[CH:52][CH:51]=[CH:50][C:49]=1[C:64]([F:67])([F:66])[F:65].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>CC(N(C)C)=O.CN1C(=O)CCC1>[CH3:26][S:27]([C:30]1[CH:31]=[CH:32][C:33]([C@@H:36]([OH:46])[C@H:37]([NH:40][C:41]([CH:43]([Cl:45])[Cl:44])=[O:42])[CH2:38][F:39])=[CH:34][CH:35]=1)(=[O:29])=[O:28].[CH3:47][C:48]1[C:53]([NH:54][C:55]2[N:60]=[CH:59][CH:58]=[CH:57][C:56]=2[C:61]([OH:63])=[O:62])=[CH:52][CH:51]=[CH:50][C:49]=1[C:64]([F:66])([F:65])[F:67]