HCID 67417031, compound → HCID 67417025, compound

HRID 1667520Notes

Reaction equation

HRID 1667520 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:9]=[C:10]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=2)[CH:11]=[CH:12][C:13]=1[Cl:14])(C)(C)C>Cl.CC(O)C>[ClH:14].[NH2:7][C:8]1[CH:9]=[C:10]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=2)[CH:11]=[CH:12][C:13]=1[Cl:14]

Participants

4

Reactant 1

HCID 67417031HCID 67417031, compound

Product 1

HCID 67417025HCID 67417025, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3776IsopropanolSolvent

Procedure

A solution of (4-chloro-3′-hydroxy-biphenyl-3-yl)-carbamic acid tert-butyl ester (1.8 g, 5.64 mmol) was dissolved in a solution of HCl in i-PrOH (5-6M, 20 mL). The resulting solution was stirred at RT for 6 hrs then concentrated to provided 3′-amino-4′-chloro-biphenyl-3-ol hydrochloride.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-08d9ad8b79cf416b841165e32fb4bf37
Source dataset
uspto-grants-2011_10
Patent number
US08044041B2

Reaction notes

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