Acetyl chloride → HCID 59239859, compound

HRID 1668393Notes

Reaction equation

HRID 1668393 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:16]C3C(=O)[N:13]([CH2:18][C:19]([C:21]4[CH:22]=[C:23]5[C:27](=[CH:28][CH:29]=4)[CH2:26][CH:25]([NH:30][CH3:31])[CH2:24]5)=[O:20])[CH:12]=[N:11][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.[C:32](Cl)(=[O:34])[CH3:33].C(N(CC)CC)C.[O:43]1CC[CH2:45][CH2:44]1>C(OCC)(=O)C.O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:16][C:33]3[C:32](=[O:34])[N:13]([CH2:18][C:19]([C:21]4[CH:22]=[C:23]5[C:27](=[CH:28][CH:29]=4)[CH2:26][CH:25]([N:30]([CH3:31])[C:44](=[O:43])[CH3:45])[CH2:24]5)=[O:20])[CH:12]=[N:11][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1

Participants

7

Reactant 4

HCID 6367Acetyl chlorideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 59239844HCID 59239844, compound

Product 1

HCID 59239859HCID 59239859, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of the compound (27 mg) obtained in Example 16, acetyl chloride (5.2 mg), triethylamine (9.2 mg) and tetrahydrofuran (1 ml) was stirred at room temperature for 30 min. The reaction mixture was diluted with ethyl acetate and water, and the precipitate was collected by filtration to give the title compound (29 mg) as a colorless powder.

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-95605fcd82db48629768ceaf8e7ace36
Source dataset
uspto-grants-2011_08
Patent number
US07989445B2

Reaction notes

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