反应详情

温度

70 °C

To a mixture of (±)-3-{4-[2-cyclohexyl-1-(4′-trifluoromethyl-biphenyl-4-yl)-ethoxy]-benzoylamino}-propionic acid tert-butyl ester (Isomer 2) (0.0865, 0.145 mmol) in THF (1.5 mL) is added LiOH (1 N aqueous, 1.4 mL) and stirred at 70° C. overnight. The reaction mixture is acidified with 1N HCl (1.5 mL) and extracted with EtOAc (3×10 mL). Combined organic extracts are dried over MgSO4, filtered, and conc. to provide 3-{4-[2-cyclohexyl-1-(4′-trifluoromethyl-biphenyl-4-yl)-ethoxy]-benzoylamino}-propionic acid (Isomer 2) (0.0706 g, 90%) as a white solid. MS (ES): 540.0 [M+H]+.

1. extractionextracted with EtOAc (3×10 mL)
2. dry with materialCombined organic extracts are dried over MgSO4
3. filtrationfiltered