反应详情

To a mixture of (±)-3-{4-[2-cyclohexyl-1-(4′-trifluoromethyl-biphenyl-4-yl)-ethoxy]-benzoylamino}-propionic acid methyl ester (0.0834, 0.151 mmol) in THF (1.0 mL) is added LiOH (1 N aqueous, 0.4 mL) and stirred at RT for 1 h. The reaction mixture is acidified with 1N HCl (0.5 mL) and extracted with EtOAc (3×5 mL). Combined organic extracts are dried over MgSO4, filtered, and conc. to provide (±)-3-{4-[2-cyclohexyl-1-(4′-trifluoromethyl-biphenyl-4-yl)-ethoxy]-benzoylamino}-propionic acid (0.0814 g, 71%) as a white solid. MS (ES): 540.3 [M+H]+.

1. extractionextracted with EtOAc (3×5 mL)
2. dry with materialCombined organic extracts are dried over MgSO4
3. filtrationfiltered