反应详情

温度

-78 °C

[(2-bromo-5-methoxybenzyl)oxy](triisopropyl)silane (1 eq) was dissolved in anhydrous THF (0.43M solution) and the solution was cooled to −78° C. A solution of n-BuLi (1.6M in hexanes, 1.05 eq) was added and the resulting mixture was stirred for 1 h at −78° C. Then triisopropyl borate (50% in THF, 1.3 eq) was added dropwise and the mixture was allowed to warm to RT overnight. 1N HCl was added and the resulting mixture was stirred at RT for 30 min. THF was removed in vacuo and replaced with Et2O. The organic phase was washed with water and with brine, then dried over Na2SO4 and evaporated in vacuo. The product was obtained as a colourless oil (64% yield, 65% pure) which was used without further purification in the next reaction.

1. temperatureto warm to RT overnight
2. stirringthe resulting mixture was stirred at RT for 30 min
3. customTHF was removed in vacuo
4. washThe organic phase was washed with water and with brine
5. dry with materialdried over Na2SO4
6. customevaporated in vacuo
7. customThe product was obtained as a colourless oil (64% yield, 65% pure) which
8. customwas used without further purification in the next reaction