Benzyl Bromide → Benzyl 2-(3-(benzyloxy)phenyl)acetate

HRID 1670339Notes

Reaction equation

HRID 1670339 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.C([O-])([O-])=O.[K+].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CN(C=O)C>[CH2:18]([O:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:8][C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)=[O:10])[CH:5]=[CH:6][CH:7]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 121223'-Hydroxyphenylacetic acid

Product 1

HCID 15470856Benzyl 2-(3-(benzyloxy)phenyl)acetate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 3-hydroxyphenylacetic acid (Acros, 3.04 g, 20 mmol) in 20 mL of DMF were added K2CO3 (6.90 g, 50 mmol) and benzyl bromide (4.75 mL, 40 mmol) at room temperature. The reaction mixture was stirred for 24 h. The suspension was filtered and washed with diethyl ether. The filtrate was then washed with brine and dried over MgSO4. Filtration, followed by concentration, provided the crude benzyl 2-(3-(benzyloxy)phenyl)acetate which was used in the next step. MS (ESI+) m/z 355 (M+Na)+.

Workup

  1. filtrationThe suspension was filtered
  2. washwashed with diethyl ether
  3. washThe filtrate was then washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationFiltration
  6. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-c11fc04207484e4e9fc6b7868895690d
Source dataset
uspto-grants-2011_08
Patent number
US07989477B2

Reaction notes

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