Hydrogen Bromide → HCID 15986278, compound

HRID 1670401Notes

Reaction equation

HRID 1670401 reaction equation
Cl[C:2]1[N:17]=[N:16][C:5]2[NH:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=1.[BrH:18]>CCOC(C)=O.[OH-].[Na+]>[Br:18][C:2]1[N:17]=[N:16][C:5]2[NH:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 49830947HCID 49830947, compound

Product 1

HCID 15986278HCID 15986278, compoundYield 36%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
100 °C

Procedure

2-Chloro-5,10-dihydro-3,4,5,10-tetraaza-dibenzo[a,d]cyclohepten-11-one from Example 2 (400 mg, 1.62 mmol) was added to HBr (10 ml, 47% in water) and heated at 100° C. for 63 hours. The solution was cooled and diluted with EtOAc and NaOH (1M). The resultant precipitate was collected by filtration, washed with EtOAc and water and then dried under vacuum to give the title compound as a white solid (170 mg, 36%).

Workup

  1. temperatureThe solution was cooled
  2. filtrationThe resultant precipitate was collected by filtration
  3. washwashed with EtOAc and water
  4. customdried under vacuum

Sources & evidence

ORD record
ord-2b9c9140edb441058e41740ea59425f6
Source dataset
uspto-grants-2011_08
Patent number
US07994160B2

Reaction notes

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