反应详情

Treat a solution of 4-bromo-2-cyclohexyl-N-(2,6-dichloro-4-methoxy-benzyl)-butyramide (2.0 g, 4.6 mmol) in THF (30 mL) with diisopropyl ethyl amine (1.19 g, 9.19 mmol) at 40° C. for 12 hours and at reflux for 6 hours. Cool the reaction, dilute with ethylacetate and wash with HCl (1N) and water. After drying the organic layer over sodium sulfate, filtrate and concentrate under vacuum. Purify the residue by silica gel chromatography with 1:4 ethyl acetate:hexane to afford 1.3 g (80%) of the title compound. MS (m/z): 356 (M+).

1. temperatureat reflux for 6 hours
2. temperatureCool
3. customthe reaction
4. washwash with HCl (1N) and water
5. dry with materialAfter drying the organic layer over sodium sulfate, filtrate
6. concentrationconcentrate under vacuum
7. customPurify the residue by silica gel chromatography with 1:4 ethyl acetate