Piperidine → 1-Butylpiperidine

HRID 1672086Notes

Reaction equation

HRID 1672086 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.I[CH2:8][CH2:9][CH2:10][CH3:11]>C(OCC)C>[CH2:8]([N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[CH2:9][CH2:10][CH3:11]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 10962Butyl iodide

Product 1

HCID 786541-Butylpiperidine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

45.0 g piperidine (0.53 mol) was added to 150 g ethyl ether. 48.6 g iodobutane (0.26 mol) was then added drop wise. After 3 days the resulting piperidine hydroiodide salt was removed by filtration and the N-butylpiperidine was recovered from the ether solution.

Workup

  1. customAfter 3 days the resulting piperidine hydroiodide salt was removed by filtration
  2. customthe N-butylpiperidine was recovered from the ether solution

Sources & evidence

ORD record
ord-e7b70704628b4aacb51b4e3d59fbfa76
Source dataset
uspto-grants-2011_08
Patent number
US07998457B2

Reaction notes

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