Trityl chloride → 1-Trityl-2-[(dimethylamino)methylene]aminoimidazole

HRID 1672088Notes

Reaction equation

HRID 1672088 reaction equation
[CH3:1][N:2]([CH:4]=[N:5][C:6]1[NH:7][CH:8]=[CH:9][N:10]=1)[CH3:3].C(N(CC)CC)C.[C:18](Cl)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(Cl)Cl>[C:18]([N:7]1[CH:8]=[CH:9][N:10]=[C:6]1[N:5]=[CH:4][N:2]([CH3:3])[CH3:1])([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 54387791HCID 54387791, compound

Product 1

HCID 673433701-Trityl-2-[(dimethylamino)methylene]aminoimidazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the crude 2-[dimethylamino)methylene]aminoimidazole (2) was added methylene chloride (750 mL), triethylamine (98 mL, 700 mmol) and trityl chloride (62.98 g, 226 mmol) (Aldrich). The reaction mixture was stirred at room temperature for 3 hrs. Solvent was removed in vacuo and the crude 3 was crystallized from methanol.

Workup

  1. customSolvent was removed in vacuo
  2. customthe crude 3 was crystallized from methanol

Sources & evidence

ORD record
ord-ed60cbbdc0d844f6978bf132e3db564d
Source dataset
uspto-grants-2011_08
Patent number
US07998462B2

Reaction notes

Loading…