Methanol → Benzoic Acid

HRID 1673389Notes

Reaction equation

HRID 1673389 reaction equation
CO.C(N[C:12]1[CH:20]=[C:19](/C=C/C2C=CC=C(OC)C=2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=O)C1C=CC=CC=1>[C].[Pd].C(OCC)(=O)C>[C:14]([OH:16])(=[O:15])[C:13]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:12]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 578794242-(benzamido)-4-((E)-2-(3-methoxyphenyl)vinyl)benzoic acid

Product 1

HCID 243Benzoic Acid

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

1.0 mL of methanol, 2.0 mL of ethyl acetate and 2.0 mg of 5% palladium-carbon were added to the obtained 2-(benzamido)-4-((E)-2-(3-methoxyphenyl)vinyl)benzoic acid and stirred under hydrogen atmosphere at room temperature for 2 hours. Insoluble were removed by filtration, and the solvent was evaporated under reduced pressure to obtain 6.3 mg of 2-(benzamido)-4-(2-3-methoxyphenyl)ethyl)benzoic acid as white solid.

Workup

  1. customInsoluble were removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-058d08704eb642b3a9c7650d9f77e25d
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

Loading…