Methanol → HCID 57879585, compound

HRID 1673451Notes

Reaction equation

HRID 1673451 reaction equation
C(=O)([O-])[O-].[K+].[K+].CO.C([O:12][C:13]1[CH:37]=[CH:36][C:16]([C:17]([NH:19][C:20]2[CH:28]=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[CH:30]=3)[CH:26]=[CH:25][C:21]=2[C:22]([OH:24])=[O:23])=[O:18])=[CH:15][CH:14]=1)(=O)C>O1CCCC1>[Cl:35][C:31]1[CH:30]=[C:29]([C:27]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[C:20]([NH:19][C:17](=[O:18])[C:16]3[CH:36]=[CH:37][C:13]([OH:12])=[CH:14][CH:15]=3)[CH:28]=2)[CH:34]=[CH:33][CH:32]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 57879386HCID 57879386, compound

Product 1

HCID 57879585HCID 57879585, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7.6 mg of potassium carbonate was added to a mixed solution of 0.5 mL of methanol and 0.5 mL of tetrahydrofuran containing 15 mg of 2-(4-acetoxybenzamido)-4-(3-chlorophenyl)benzoic acid and stirred at room temperature for 2 hours. After insoluble were removed by filtration, 10% citric acid aqueous solution was added and a solid substance was separated by filtration to obtain 10 mg of 4-(3-chlorophenyl)-2-(4-hydroxybenzamido)benzoic acid as white solid.

Workup

  1. customAfter insoluble were removed by filtration, 10% citric acid aqueous solution
  2. additionwas added
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-bf1586531d9f454f8204b17b92a5cb35
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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