Citric Acid → HCID 57879535, compound

HRID 1673506Notes

Reaction equation

HRID 1673506 reaction equation
CO.C(=O)([O-])[O-].[K+].[K+].C([O:12][C:13]1[CH:14]=[C:15]([CH:34]=[CH:35][CH:36]=1)[C:16]([NH:18][C:19]1[CH:27]=[C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=[O:22])=[O:17])(=O)C.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O1CCCC1>[OH:12][C:13]1[CH:14]=[C:15]([CH:34]=[CH:35][CH:36]=1)[C:16]([NH:18][C:19]1[CH:27]=[C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=[O:22])=[O:17]

Participants

6

Reactant 4

HCID 311Citric AcidHCID 887MethanolHCID 11430Potassium CarbonateHCID 57879462HCID 57879462, compound

Product 1

HCID 57879535HCID 57879535, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 8.3 mg of potassium carbonate were added to 15 mg of 2-(3-acetoxybenzamido)-4-phenylbenzoic acid at room temperature sequentially and stirred at the same temperature for 2 hours. 10% citric acid aqueous solution was added to the reaction mixture and a solid substance was separated by filtration to obtain 12 mg of 2-(3-hydroxybenzamido)-4-phenylbenzoic acid as while solid.

Workup

  1. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-5a54ca2c9e2248b0880afbe90fa0259e
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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