Citric Acid → HCID 57879544, compound

HRID 1673507Notes

Reaction equation

HRID 1673507 reaction equation
CO.C(=O)([O-])[O-].[K+].[K+].C([O:12][C:13]1[CH:14]=[C:15]([CH:35]=[CH:36][CH:37]=1)[C:16]([NH:18][C:19]1[CH:27]=[C:26]([O:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=[O:22])=[O:17])(=O)C.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O1CCCC1>[OH:12][C:13]1[CH:14]=[C:15]([CH:35]=[CH:36][CH:37]=1)[C:16]([NH:18][C:19]1[CH:27]=[C:26]([O:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=[O:22])=[O:17]

Participants

6

Reactant 4

HCID 311Citric AcidHCID 887MethanolHCID 11430Potassium CarbonateHCID 57879340HCID 57879340, compound

Product 1

HCID 57879544HCID 57879544, compoundYield 61.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 4.2 mg of potassium carbonate were added sequentially to 8.0 mg of 2-(3-acetoxybenzamido)-4-phenoxybenzoic acid at room temperature and stirred at the same temperature for 2 hours. 10% citric acid aqueous solution was added to the reaction mixture and a solid substance was separated by filtration to obtain 4.4 mg of 2-(3-hydroxybenzamido)-4-phenoxybenzoic acid as whine solid.

Workup

  1. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-49b31cb3d2fe46fe824f64e144b0522d
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

Loading…