Trifluoroacetic acid → HCID 67342322, compound

HRID 1673517Notes

Reaction equation

HRID 1673517 reaction equation
FC(F)(F)C(O)=O.[ClH:8].O1CCOCC1.[C:15]([NH:23][C:24]1[CH:32]=[C:31]([N:33]2[C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=3[N:35]=[CH:34]2)[CH:30]=[CH:29][C:25]=1[C:26]([OH:28])=[O:27])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(OCC)(=O)C>[ClH:8].[C:15]([NH:23][C:24]1[CH:32]=[C:31]([N:33]2[C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=3[N:35]=[CH:34]2)[CH:30]=[CH:29][C:25]=1[C:26]([OH:28])=[O:27])(=[O:22])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 204431481,4-Dioxane hydrochlorideHCID 57879432HCID 57879432, compound

Product 1

HCID 67342322HCID 67342322, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

0.5 mL of trifluoroacetic acid and 0.01 mL of 4.0 mol/L hydrogen chloride/dioxane were added to 1.0 mL suspension containing 15 mg of 2-(benzamido)-4-(1H-benzimidazol-1-yl)benzoic acid in ethyl acetate sequentially while ice-cooled and stirred at the same temperature for 10 minutes. A solid substance was separated by filtration to obtain 12 mg of 2-(benzamido)-4-(1H-benzimidazol-1-yl)benzoic acid hydrochloride as white solid.

Workup

  1. temperaturecooled
  2. customA solid substance was separated by filtration

Sources & evidence

ORD record
ord-024806cc512a4195a87276eddd76389b
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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