Hydrochloric Acid → HCID 57879550, compound

HRID 1673555Notes

Reaction equation

HRID 1673555 reaction equation
[OH-].[Na+].CO.[C:5]([NH:13][C:14]1[CH:23]=[C:22]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([Cl:31])[CH:26]=2)[CH:21]=[CH:20][C:15]=1[C:16]([O:18]C)=[O:17])(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.Cl>O.O1CCCC1>[C:5]([NH:13][C:14]1[CH:23]=[C:22]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([Cl:31])[CH:26]=2)[CH:21]=[CH:20][C:15]=1[C:16]([OH:18])=[O:17])(=[O:12])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 57879300HCID 57879300, compound

Product 1

HCID 57879550HCID 57879550, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

0.16 mL of 2.0 mol/L aqueous sodium hydroxide was added to a mixed solution of 1.0 mL of methanol and 1.0 mL of tetrahydrofuran containing 0.10 g of methyl 2-(benzamido)-4-(3-chlorophenoxy)benzoate while ice-cooled and stirred at room temperature for 5 hours. The reaction mixture was added to water and 1.0 mol/L hydrochloric acid while ice-cooled, and a solid substance was separated by filtration to obtain 92 mg of 2-(benzamido)-4-(3-chlorophenoxy)benzoic acid as white solid.

Workup

  1. temperaturecooled
  2. temperaturecooled
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-b929b6a212d34c7594bbcd3c259c3f3a
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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