Cesium carbonate → HCID 59469468, compound

HRID 1674399Notes

Reaction equation

HRID 1674399 reaction equation
Br[CH2:2][CH:3]1[CH2:5][CH2:4]1.C(=O)([O-])[O-].[Cs+].[Cs+].[OH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:24](=[O:25])[N:23]([CH2:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]4[C:34]([C:39]#[N:40])=[CH:35][CH:36]=[CH:37][CH:38]=4)=[CH:29][CH:28]=3)[C:22]([CH2:41][CH2:42][CH3:43])=[N:21][C:20]=2[CH3:44])=[CH:15][CH:14]=1>CN(C)C=O.C(OCC)(=O)C>[CH:5]1([CH2:4][O:12][C:13]2[CH:14]=[CH:15][C:16]([C:19]3[C:24](=[O:25])[N:23]([CH2:26][C:27]4[CH:32]=[CH:31][C:30]([C:33]5[C:34]([C:39]#[N:40])=[CH:35][CH:36]=[CH:37][CH:38]=5)=[CH:29][CH:28]=4)[C:22]([CH2:41][CH2:42][CH3:43])=[N:21][C:20]=3[CH3:44])=[CH:17][CH:18]=2)[CH2:3][CH2:2]1

Participants

6

Reactant 3

HCID 10796Cesium carbonateHCID 81503BromomethylcyclopropaneHCID 67201771HCID 67201771, compound

Product 1

HCID 59469468HCID 59469468, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of (bromomethyl)cyclopropane (0.17 mL), cesium carbonate (1.7 g) and 4′-{[5-(4-hydroxyphenyl)-4-methyl-6-oxo-2-propylpyrimidin-1(6H)-yl]methyl}biphenyl-2-carbonitrile (0.5 g) in N,N-dimethylformamide (5 mL) was stirred for 2 hr at 80° C. The reaction mixture was diluted with ethyl acetate, washed with 1 M hydrochloric acid, dried over sodium sulfate and concentrated. The residue was purified by silica gel column chromatography to give the title compound as a pale yellow oil (0.56 g, 100%).

Workup

  1. washwashed with 1 M hydrochloric acid
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated
  4. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-fd63421f6e8749b6918d4045ff0a3e62
Source dataset
uspto-grants-2011_08
Patent number
US07998968B2

Reaction notes

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