Trifluoroacetic acid → HCID 57511295, compound

HRID 1674623Notes

Reaction equation

HRID 1674623 reaction equation
C([O:5][C:6](=[O:32])[CH2:7][N:8]([C:22]1[CH:27]=[C:26]([N:28]([CH3:30])[CH3:29])[CH:25]=[CH:24][C:23]=1[Cl:31])[S:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=1)(=[O:11])=[O:10])(C)(C)C.C([SiH](CC)CC)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:31][C:23]1[CH:24]=[CH:25][C:26]([N:28]([CH3:29])[CH3:30])=[CH:27][C:22]=1[N:8]([CH2:7][C:6]([OH:32])=[O:5])[S:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=1)(=[O:10])=[O:11]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 67338427HCID 67338427, compound

Product 1

HCID 57511295HCID 57511295, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of [(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid tert-butylester (1.160 g) in dry DCM (5.5 mL) were added successively triethylsilane (0.423 mL) and TFA (4.8 mL).

Sources & evidence

ORD record
ord-ca1263811a34496284e24bfe16dce42b
Source dataset
uspto-grants-2011_08
Patent number
US08003654B2

Reaction notes

Loading…