反应详情

To a solution of ethyl 2,5-dioxopyrrolidine-3-carboxylate (2.96 g) in ethyl acetate (25 ml) was added di-tert-butyl azodicarboxylate (4.19 g), followed by potassium carbonate (4.78 g) at room temperature. After this reaction mixture was stirred at room temperature for 15 minutes, the resulting mixture was filtered through a Celite pad and the filtrate was concentrated. The residue was purified by a flash column chromatography (hexane:ethyl acetate=3:1) to give the desired product (5.77 g, 83%) as amorphous.

1. filtrationthe resulting mixture was filtered through a Celite pad
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by a flash column chromatography (hexane:ethyl acetate=3:1)