反应详情

LiOH (1.2 mL, 1.19 mmol, 1.0 M in H2O) was added to a solution of methyl 1-(4-fluorophenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate (0.149 g, 0.593 mmol) in a mixture of THF (4.5 mL) and MeOH (1.5 mL) at room temperature for 1 hour. The reaction mixture was acidified with aq. 1 N HCl solution (1.4 mL), extracted with EtOAc, washed with brine, dried over MgSO4, and concentrated to afford the desired product (0.13 g, 92%). 1H-NMR (400 MHz, CD3OD) δ 7.62 (m, 2H), 7.13 (t, 2H), 3.97 (m, 1H), 3.86 (m, 1H), 2.63 (m, 1H), 2.13 (m, 1H), 1.47 (s, 3H); 19F NMR (376 MHz, CD3OD) δ −119.3.

1. extractionextracted with EtOAc
2. washwashed with brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated