Trifluoroacetic acid → HCID 86622851, compound

HRID 1676899Notes

Reaction equation

HRID 1676899 reaction equation
C([O:5][C:6](=[O:16])[C@H:7]([CH3:15])[CH2:8][C:9]([NH:11][CH2:12][CH:13]=[CH2:14])=[O:10])(C)(C)C.C([SiH](CC)CC)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:12]([NH:11][C:9](=[O:10])[CH2:8][C@@H:7]([CH3:15])[C:6]([OH:16])=[O:5])[CH:13]=[CH2:14]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 86622852HCID 86622852, compound

Product 1

HCID 86622851HCID 86622851, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1.98 g (8.7 mmol) of (R)—N-allyl-2-methyl-succinamic acid tert-butyl ester in 30 ml of DCM are added 3.57 ml (21.8 mmol) of triethylsilane and 8.76 ml (113 mmol) of TFA, and the mixture is stirred for 3 h and then concentrated by co-evaporation with toluene (3×30 ml) to give the solid product.

Workup

  1. concentrationconcentrated by co-evaporation with toluene (3×30 ml)
  2. customto give the solid product

Sources & evidence

ORD record
ord-e554d97d768048d5ae3b515478f1de94
Source dataset
uspto-grants-2011_08
Patent number
US08008250B2

Reaction notes

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