1,2-Dichloroethane → HCID 11633092, compound

HRID 1676922Notes

Reaction equation

HRID 1676922 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([O:7][C:8]2[C:9]([N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:10][C:11]([C:18](O)=[O:19])=[CH:12][C:13]=2[S:14]([NH2:17])(=[O:16])=[O:15])=[CH:5][CH:6]=1.C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.[CH2:40]([NH:42][CH2:43][CH3:44])[CH3:41]>CN(C=O)C>[CH2:40]([N:42]([CH2:43][CH3:44])[C:18](=[O:19])[C:11]1[CH:10]=[C:9]([N:21]2[CH2:22][CH2:23][CH2:24][CH2:25]2)[C:8]([O:7][C:4]2[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=2)=[C:13]([S:14]([NH2:17])(=[O:15])=[O:16])[CH:12]=1)[CH3:41]

Participants

6

Reactant 4

HCID 111,2-DichloroethaneHCID 4849PiretanideHCID 8021DiethylamineHCID 757711-Hydroxybenzotriazole

Product 1

HCID 11633092HCID 11633092, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar manner to Example 7, piretanide can be reacted with EDC, HOBt and diethylamine in DMF to yield N,N-diethyl 3-aminosulfonyl-4-phenoxy-5-(1-pyrrolidinyl)-benzamide.

Sources & evidence

ORD record
ord-4ea2e864212c461282a5b2dc458f9444
Source dataset
uspto-grants-2011_08
Patent number
US08008283B2

Reaction notes

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