Hydrochloric Acid → HCID 10248012, compound

HRID 1676997Notes

Reaction equation

HRID 1676997 reaction equation
[NH2:1][C:2]([C:4]1[NH:5][C:6]2[C:11]([C:12]=1[S:13]([NH:16][CH2:17][CH2:18][NH:19]C(=O)OC(C)(C)C)(=[O:15])=[O:14])=[CH:10][C:9]([Br:27])=[CH:8][CH:7]=2)=[O:3].Cl>CCOC(C)=O>[NH2:19][CH2:18][CH2:17][NH:16][S:13]([C:12]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Br:27])[CH:10]=2)[NH:5][C:4]=1[C:2]([NH2:1])=[O:3])(=[O:14])=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10049933HCID 10049933, compound

Product 1

HCID 10248012HCID 10248012, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Through a solution of the product from Example 62, Step B (113 mg, 0.245 mmols) in 20 mL of EtOAc at 0° C. was bubbled HCl gas for 3 minutes. The reaction was sealed, and stirring continued for 45 minutes. The solvent was removed in vacuo to give the titled compound. ESI+ MS: 361 [M+H]+.

Workup

  1. customThe reaction was sealed
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-4b5e8708ebad485494866f0d675ae67a
Source dataset
uspto-grants-2011_08
Patent number
US08008295B2

Reaction notes

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